2020 04 02; 22(1):21. 2002 11 01; 544(3):817-30. Stephanie Myers. J R Soc Interface. Kerckhoffs RC, Narayan SM, Omens JH, Mulligan LJ, McCulloch AD. 2015 recipient of a Ledell Family Science and Engineering Undergraduate Research Scholarship. An Iterative Diffeomorphic Algorithm for Registration of Subdivision Surfaces: Application to Congenital Heart Disease. Emery JL, Omens JH, McCulloch AD. Stat Atlases Comput Models Heart. 2015 Jan; 8896:63-73. Adv Exp Med Biol. Important phenotyping techniques in the mouse include optical electrical mapping, isolated muscle mechanics testing and magnetic resonance imaging. Kim McCabe, a graduate student in Andrew McCulloch’s group and ours, was appointed to the prestigious Gordon Scholars Program in our Jacobs School of Engineering. PMID: 32866086. Powers JD, Yuan CC, McCabe KJ, Murray JD, Childers MC, Flint GV, Moussavi-Harami F, Mohran S, Castillo R, Zuzek C, Ma W, Daggett V, McCulloch AD, Irving TC, Regnier M. PMID: 31110001. J Biol Chem. See a roster and contact information for Organized Research Units (ORUs) at UC San Diego. UCSD Interfaces Graduate Training Program 9500 Gilman Drive, Dept 0412 La Jolla, Ca 92093-0412 Program Director: Andrew McCulloch http://cmrg.ucsd.edu/AndrewMcCulloch Lee AA, Dillmann WH, McCulloch AD, Villarreal FJ. Model of Human Fetal Growth in Hypoplastic Left Heart Syndrome: Reduced Ventricular Growth Due to Decreased Ventricular Filling and Altered Shape. Nour Marogy. Am J Physiol. Prof. Andrew McCulloch, Department of Bioengineering, email: . 1998 Sep-Oct; 26(5):743-55. 2020 Jun 12; 378(2173):20190336. 1991 Feb; 113(1):42-55. Dr. Andrew McCulloch is Distinguished Professor of Bioengineering and Medicine at the University of California San Diego and Director of the Institute for Engineering in Medicine. 2000 Aug; 47(2):284-93. Saucerman JJ, Brunton LL, Michailova AP, McCulloch AD. Atlas-Based Ventricular Shape Analysis for Understanding Congenital Heart Disease. Guccione JM, McCulloch AD. Articles Cited by. PKA phosphorylation of cardiac troponin I modulates activation and relaxation kinetics of ventricular myofibrils. Acetylcholine-induced shortening of the epicardial action potential duration may increase repolarization gradients and LQT3 arrhythmic risk. PMID: 12433833. Cardiovasc Res. Office Hours: by appointment. PMID: 32448062. An equibiaxial strain system for cultured cells. k4zhang@ucsd.edu. 2003 Apr; 1(4):267-77. Biomed Res Int. . Lorenzen-Schmidt I, Schmid-Schönbein GW, Giles WR, McCulloch AD, Chien S, Omens JH. PMID: 18593662. Saucerman JJ, McCulloch AD. Flexibility in energy metabolism supports hypoxia tolerance in Drosophila flight muscle: metabolomic and computational systems analysis. J Phys Chem B. Desmosomal junctions are necessary for adult sinus node function. Reliability of Soil-Structure-Foundation Systems. Front Pediatr. Cardiovasc Res. 2008 Dec; 118(12):3870-80. 2020 Jun; 19(3):1079-1089. Mechanisms of transmurally varying myocyte electromechanics in an integrated computational model. PMID: 23666676. Organized Research Units. New Role Found for a Cardiac Progenitor Population. Costa KD, Takayama Y, McCulloch AD, Covell JW. 2006 Oct; 1080:348-61. Lim BK, Xiong D, Dorner A, Youn TJ, Yung A, Liu TI, Gu Y, Dalton ND, Wright AT, Evans SM, Chen J, Peterson KL, McCulloch AD, Yajima T, Knowlton KU. Faculty Advisor: Adjt Professor Bruce Wheeler (858) 534-6458, bcwheeler@ucsd.edu. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing. 2001 Jul 17; 104(3):336-41. Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytes. Am J Physiol. FASEB J. Kim McCabe, a graduate student in Andrew McCulloch’s group and ours, was appointed to the prestigious Gordon Scholars Program in our Jacobs School of Engineering. PMID: 33104742. 2003 Oct; 36(5):241-54. Structural basis of regional dysfunction in acutely ischemic myocardium. 2010 Oct 28; 6(10):e1000972. PMID: 2702734. Name Email Title Home Department IEM Affiliated Center; Pedro J. Cabrales: pcabrales@ucsd.edu Yang PC, Purawat S, Ieong PU, Jeng MT, DeMarco KR, Vorobyov I, McCulloch AD, Altintas I, Amaro RE, Clancy CE. A three-dimensional finite element method for large elastic deformations of ventricular myocardium: II--Prolate spheroidal coordinates. Structural contributions to fibrillatory rotors in a patient-derived computational model of the atria. Properties of cardiac conduction in a cell-based computational model. Kekenes-Huskey PM, Liao T, Gillette AK, Hake JE, Zhang Y, Michailova AP, McCulloch AD, McCammon JA. 2009 Apr; 13(2):362-9. PMID: 23104917. PMID: 9083843. Pfeiffer ER, Tangney JR, Omens JH, McCulloch AD. PLoS Comput Biol. Cheng Y, Lindert S, Kekenes-Huskey P, Rao VS, Solaro RJ, Rosevear PR, Amaro R, McCulloch AD, McCammon JA, Regnier M. PMID: 25296321. Ann Biomed Eng. Muscle LIM protein deficiency leads to alterations in passive ventricular mechanics. PMID: 11299225. Distributed mechanics of the canine right ventricle: effects of varying preload. Med Image Anal. Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy. PMID: 11454551. 2012 Oct-Nov; 110(2-3):295-304. Ann Biomed Eng. Left ventricular geometric remodeling and residual stress in the rat heart. Dr. Andrew McCulloch is Distinguished Professor of Bioengineering and Medicine at the University of California San Diego and Director of the Institute for Engineering in Medicine. MAAMD: a workflow to standardize meta-analyses and comparison of affymetrix microarray data. 2006; 1(3):1379-91. McCulloch AD, Harris AB, Sarraf CE, Eastwood M. PMID: 15165473. Heart Lung Circ. JCI Insight. 2019 12; 10(4):553-567. Prog Pediatr Cardiol. McClymont D, Teh I, Carruth E, Omens J, McCulloch A, Whittington HJ, Kohl P, Grau V, Schneider JE. Sung D, Mills RW, Schettler J, Narayan SM, Omens JH, McCulloch AD. Zambon AC, Hsu T, Kim SE, Klinck M, Stowe J, Henderson LM, Singer D, Patam L, Lim C, McCulloch AD, Hu B, Hickerson AI. Left ventricular form and function: scientific priorities and strategic planning for development of new views of disease. PLoS One. Invest Ophthalmol Vis Sci. Cardiovasc Res. Name. 2009 Sep 09; 3:91. 1996 Mar; 29(3):373-81. 2020 Jul 03; 127(2):284-297. Usyk TP, Omens JH, McCulloch AD. John Moody joins the group as a postdoc, starting 1 July. Cranford JP, O'Hara TJ, Villongco CT, Hafez OM, Blake RC, Loscalzo J, Fattebert JL, Richards DF, Zhang X, Glosli JN, McCulloch AD, Krummen DE, Lightstone FC, Wong SE. PMID: 19740440. Campbell SG, Flaim SN, Leem CH, McCulloch AD. 2019 03; 597(6):1531-1551. PMID: 11029401. Members of the Graduate Affairs Committee: Assoc Professor Pedro Cabrales, Chair (858) 534-8197 PFBH 182 pcabrales@ucsd.edu. 1998 Dec; 120(6):710-4. 2013 Jul 15; 305(2):H192-202. Sanna MG, Vincent KP, Repetto E, Nguyen N, Brown SJ, Abgaryan L, Riley SW, Leaf NB, Cahalan SM, Kiosses WB, Kohno Y, Brown JH, McCulloch AD, Rosen H, Gonzalez-Cabrera PJ. PMID: 25202018. Instructors. See a roster and contact information for Organized Research Units (ORUs) at UC San Diego. Ferguson LR, Browning BL, Huebner C, Petermann I, Shelling AN, Demmers P, McCulloch A, Gearry RB, Barclay ML, Philpott M. PMID: 18394979. 2008 Jun-Jul; 97(2-3):367-82. PMID: 10412453. Regional variations in ex-vivo diffusion tensor anisotropy are associated with cardiomyocyte remodeling in rats after left ventricular pressure overload. Nonuniform muscle fiber orientation causes spiral wave drift in a finite element model of cardiac action potential propagation. UC-San Diego Paige Shapiro Undergraduate Researcher, 2014-2015 BS/MS student, 2015-2016 . BISB Research Area(s): Dynamical Systems, Stochastic Processes, and Biological Circuits; Structural Bioinformatics and Systems Pharmacology; Research Focus: Mathematical Modeling of Heart Cells and Tissue Waldman LK, Allen JJ, Pavelec RS, McCulloch AD. PMID: 22010742. PMID: 23729839. He also serves on the Executive Council of the International Union of Physiological Sciences. PMID: 27670633. Automated measurement of myofiber disarray in transgenic mice with ventricular expression of ras. Prof. Rommie Amaro, Department of Chemistry and Biochemistry, email: ramaro@ucsd.edu. J Biomech Eng. Am J Physiol. PMID: 12514807. Meng P, Irturk A, Kastner R, McCulloch A, Omens J, Wright A. PMID: 23366201. Arrhythmogenic consequences of Na+ channel mutations in the transmurally heterogeneous mammalian left ventricle: analysis of the I1768V SCN5A mutation. 1995 Oct; 28(10):1167-77. Philos Trans A Math Phys Eng Sci. J Biomech Eng. PMID: 29527171. Tissue engineering of biological cardiovascular system surrogates. Biophys J. amcculloch@ucsd.edu. 2014; 17(6):604-15. PMID: 8550635. Bioinformatics. Timing and magnitude of systolic stretch affect myofilament activation and mechanical work. All rights reserved. Suinesiaputra A, McCulloch AD, Nash MP, Pontre B, Young AA. PMID: 18586852. 1998; 69(2-3):463-81. PMID: 7810735. Deficiency of actinin-associated LIM protein alters regional right ventricular function and hypertrophic remodeling. PMID: 28468977. Van Leuven SL, Waldman LK, McCulloch AD, Covell JW. This graph shows the total number of publications by year. Members of the Graduate Affairs Committee: Assoc Professor Pedro Cabrales, Chair (858) 534-8197 PFBH 182 pcabrales@ucsd.edu. J Biomech Eng. Gilles G, McCulloch AD, Brakebusch CH, Herum KM. Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model. 1982 Jul; 243(1):R7-17. John received his PhD in mathematics at UCSD, working with Mike Holst. Numerical analysis of Ca2+ signaling in rat ventricular myocytes with realistic transverse-axial tubular geometry and inhibited sarcoplasmic reticulum. 2016 Mar; 43:27-38. 2010 Feb; 1188:121-7. McCulloch AD, Smaill BH, Hunter PJ. Finite element stress analysis of left ventricular mechanics in the beating dog heart. Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM. PMID: 24509246. 2014 Nov; 16 Suppl 4:iv3-iv10. Michailova A, Saucerman J, Belik ME, McCulloch AD. 2020 10 01; 52(10):468-477. Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts. 2017 11; 130(Pt B):404-417. J Biomech Eng. 2003; 36 Suppl:57-61. J Electrocardiol. Quinn TA, Granite S, Allessie MA, Antzelevitch C, Bollensdorff C, Bub G, Burton RA, Cerbai E, Chen PS, Delmar M, Difrancesco D, Earm YE, Efimov IR, Egger M, Entcheva E, Fink M, Fischmeister R, Franz MR, Garny A, Giles WR, Hannes T, Harding SE, Hunter PJ, Iribe G, Jalife J, Johnson CR, Kass RS, Kodama I, Koren G, Lord P, Markhasin VS, Matsuoka S, McCulloch AD, Mirams GR, Morley GE, Nattel S, Noble D, Olesen SP, Panfilov AV, Trayanova NA, Ravens U, Richard S, Rosenbaum DS, Rudy Y, Sachs F, Sachse FB, Saint DA, Schotten U, Solovyova O, Taggart P, Tung L, Varró A, Volders PG, Wang K, Weiss JN, Wettwer E, White E, Wilders R, Winslow RL, Kohl P. PMID: 21745496. Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction. Cell. Omens JH, May KD, McCulloch AD. Kerckhoffs RC, Campbell SG, Flaim SN, Howard EJ, Sierra-Aguado J, Mulligan LJ, McCulloch AD. Magnes Res. 2001 May; 29(5):414-26. Bluhm WF, Lew WY, Garfinkel A, McCulloch AD. Karlon WJ, Hsu PP, Li S, Chien S, McCulloch AD, Omens JH. Andrew D. McCulloch's 454 research works with 16,457 citations and 7,843 reads, including: Computational models of cardiovascular regulatory mechanisms Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens JH, Heller Brown J, Bers DM, McCulloch AD. In spite of these successes, there remained unmet opportunities at UCSD. PMID: 21967898. . Gregersen H, Weis SM, McCulloch AD. 2016 Aug; 2016:1228-1231. Mol Cell Biomech. . PMID: 9988000. Mechanoelectric feedback in a model of the passively inflated left ventricle. MacKenna DA, Vaplon SM, McCulloch AD. Role of diastolic properties in the transition to failure in a mouse model of the cardiac dilatation. Tveito A, Lines GT, Li P, McCulloch A. PMID: 21675815. Andrew McCulloch Academic Affairs •"My immediate supervisor, Dr. Andrew McCulloch is a great boss and I feel lucky to work with him these last five years. 2014 Sep 02; 107(5):1196-1204. 2012 Sep 15; 590(18):4403-22. 2006 Dec; 291(6):H2971-9. 1998 12; 252(4):612-25. 2012 Recipient of an AHA Summer Undergraduate Fellowship. Chen L, McCulloch AD, May-Newman K. PMID: 15675673. He 2017 Nov; 13(11):e1005854. Calcium and IP3 dynamics in cardiac myocytes: experimental and computational perspectives and approaches. 2008 Mar; 1123:169-77. Cardiac bioengineering Heart disease Cardiac biophysics Multiscale modeling. 2014 Aug 01; 307(3):H353-60. Nature. Proc Natl Acad Sci U S A. Cheng Y, Rao V, Tu AY, Lindert S, Wang D, Oxenford L, McCulloch AD, McCammon JA, Regnier M. PMID: 26391394. May-Newman K, Mathieu-Costello O, Omens JH, Klumb K, McCulloch AD. Michailova AP, Belik ME, McCulloch AD. 2012; 2012:1558-61. 2006 Sep; 20(11):1865-73. Gregersen H, Emery JL, McCulloch AD. Mazhari R, Omens JH, Pavelec RS, Covell JW, McCulloch AD. 1999 Oct; 31(10):1833-43. Multiaxial myocardial mechanics and extracellular matrix remodeling: mechanochemical regulation of cardiac fibroblast function. Hake J, Edwards AG, Yu Z, Kekenes-Huskey PM, Michailova AP, McCammon JA, Holst MJ, Hoshijima M, McCulloch AD. Front Physiol. Atlas-Based Computational Analysis of Heart Shape and Function in Congenital Heart Disease. J Electrocardiol. Tangney JR, Chuang JS, Janssen MS, Krishnamurthy A, Liao P, Hoshijima M, Wu X, Meininger GA, Muthuchamy M, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens JH. Dance band on the Titanic: biomechanical signaling in cardiac hypertrophy. 1998; 69(2-3):289-331. Perspectives on Sharing Models and Related Resources in Computational Biomechanics Research. 01/2017 - Now. Am J Physiol. Patient-Specific Models of Cardiac Biomechanics. PMID: 18598988. . Biophys J. The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias. 2020 02 04; 9(3):e013518. PMID: 30588629. PMID: 15466954. Biophys J. Mechanics of active contraction in cardiac muscle: Part II--Cylindrical models of the systolic left ventricle. Myocardial mechanics and collagen structure in the osteogenesis imperfecta murine (oim). Arch Biochem Biophys. In spite of these successes, there remained unmet opportunities at UCSD. Contributions of sustained INa and IKv43 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes. Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary. Ann N Y Acad Sci. Ann N Y Acad Sci. 2007 Jun; 4(6):768-78. Kekenes-Huskey PM, Cheng Y, Hake JE, Sachse FB, Bridge JH, Holst MJ, McCammon JA, McCulloch AD, Michailova AP. Residual strain in ischemic ventricular myocardium. J Biol Chem. The experiments in this course have been funded through internal UCSD sources, donations from the UCSD research laboratories of the late Theodore Bullock, Harvey Karten, David Kleinfeld, Mu-ming Poo and Douglas Smith, grants from the NSF (PHY to David Kleinfeld and IGERT to Terrance Sejnowski), and HHMI/NIBIB and NIBIB training grants (to Andrew McCulloch). Rao V, Cheng Y, Lindert S, Wang D, Oxenford L, McCulloch AD, McCammon JA, Regnier M. PMID: 25185555. Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis. PMID: 11375275. Guccione JM, Waldman LK, McCulloch AD. Andrew McCulloch Shu Chien Chancellor's Endowed Chair in Engineering and Medicine and Director, Institute of Engineering in Medicine at UC San Diego Cardiac image modelling: Breadth and depth in heart disease. 2005 Jul; 33(7):888-96. 2000 Mar; 278(3):H898-906. Dr. Andrew McCulloch is Distinguished Professor of Bioengineering and Medicine at the University of California San Diego and Director of the Institute for Engineering in Medicine. Li W, Gurev V, McCulloch AD, Trayanova NA. PMID: 32202936. 2009; 4(4):e5046. Angiotensin II stimulates the autocrine production of transforming growth factor-beta 1 in adult rat cardiac fibroblasts. Cardiac systems biology. Biomaterials. Chuang JS, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens JH. PMID: 18480752. Aboelkassem Y, McCabe KJ, Huber GA, Regnier M, McCammon JA, McCulloch AD. Med Image Anal. Europace. UC-San Diego. UC San Diego is at the forefront of bioengineering. Prog Biophys Mol Biol. 2019 05; 15(5):e1007042. Prog Biophys Mol Biol. Schilling JM, Horikawa YT, Zemljic-Harpf AE, Vincent KP, Tyan L, Yu JK, McCulloch AD, Balijepalli RC, Patel HH, Roth DM. Summerour SR, Emery JL, Fazeli B, Omens JH, McCulloch AD. View the profiles of professionals named "Andrew Mcculloch" on LinkedIn. 2014 Oct 07; 107(7):1675-85. Calzolari D, Bruschi S, Coquin L, Schofield J, Feala JD, Reed JC, McCulloch AD, Paternostro G. PMID: 19112483. PMID: 24209858. 2016 10; 33:38-43. 2012 Sep 15; 590(18):4401-2. Stuyvers BD, McCulloch AD, Guo J, Duff HJ, ter Keurs HE. Multiscale modeling in rodent ventricular myocytes. May-Newman K, McCulloch AD. PMID: 17390366. Improvement in pump function with endocardial biventricular pacing increases with activation time at the left ventricular pacing site in failing canine hearts. 3D printed micro-scale force gauge arrays to improve human cardiac tissue maturation and enable high throughput drug testing. 2001 Aug; 281(2):H506-14. Copyright © The Regents of the University of California, Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Lab Assistant, 2012-2014. Biophys J. Mol Cell Biomech. Director of the Institute of Engineering in Medicine, Distinguished Professor, Bioengineering, UC San Diego Adjunct Professor, Medicine, UC San Diego. Scientific Planning Committee. Gradients of epicardial strain across the perfusion boundary during acute myocardial ischemia. Microsc Microanal. Regional myocardial perfusion and mechanics: a model-based method of analysis. Mcculloch, Andrew UCSD; Chien, Kenneth UCSD; Teerlink, John UCSF; Explore _ Same Department Chen, Albert; Kwon, Ester; Luo, Colin; Ngo, Kim; Zhong, Sheng; Search Department _ UCSD Profiles is managed by the UC San Diego Altman Clinical and Translational Research Institute (ACTRI). PMID: 31810659. 2010 May 19; 98(10):2254-64. PMID: 8576949. 2014 recipient of the Ledell Family Research Scholarship 2016 graduated MSc UC-San Diego: Meagan Wu Volunteer, 2013-2014 Canyon Crest Academy Stanford University Stephanie Yuan Volunteer, 2014-2015 Torrey Pines High School Georgetown University Large-scale finite element analysis of the beating heart. Application due date will be announced winter 2018. Functionally and structurally integrated computational modeling of ventricular physiology. PMID: 27349830. PMID: 19251984. 2009 May; 94(5):541-52. Anterior and posterior left ventricular sarcomere lengths behave similarly during ejection. 2007 Jan; 35(1):1-18. Ann Biomed Eng. MacKenna DA, Omens JH, McCulloch AD, Covell JW. PMID: 23561539. 1996 Nov; 118(4):464-72. 1994 Jun; 74(6):1166-78. 1993 Nov; 115(4B):497-502. Specialization in Multi-Scale Biology. PMID: 32782827. J Biomech. Vincent KP, Forsch N, Govil S, Joblon JM, Omens JH, Perry JC, McCulloch AD. He served as Vice Chair of the Bioengineering Department from 2002 to 2005 and Chair from 2005 to 2008. Multi-core CPU or GPU-accelerated Multiscale Modeling for Biomolecular Complexes. Am J Physiol. Shah SJ, Borlaug BA, Kitzman DW, McCulloch AD, Blaxall BC, Agarwal R, Chirinos JA, Collins S, Deo RC, Gladwin MT, Granzier H, Hummel SL, Kass DA, Redfield MM, Sam F, Wang TJ, Desvigne-Nickens P, Adhikari BB. PMID: 24621103. An integrative appraisal of mechano-electric feedback mechanisms in the heart. J Cardiovasc Electrophysiol. Flaim SN, Giles WR, McCulloch AD. 2017 Jul 07; 28(14):1871-1882. CAP aims to develop a shareable and web-accessible atlas of normal and pathological heart structure and function. Acta Biomater. View in: PubMed Mentions: SEEKR: Simulation Enabled Estimation of Kinetic Rates, A Computational Tool to Estimate Molecular Kinetics and Its Application to Trypsin-Benzamidine Binding. UC San Diego: Andrew McCulloch: Maria Rodriguez is a freshman Bioengineering major who worked in the lab of Dr. Andrew McCulloch, Bioengineering Department. Tissue-Specific Optical Mapping Models of Swine Atria Informed by Optical Coherence Tomography. Kerckhoffs RC, Omens JH, McCulloch AD. PLoS Comput Biol. Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation. Cell proliferation rates in an artificial tissue-engineered environment. PMID: 11400722. PMID: 9779958. Modeling regulation of cardiac KATP and L-type Ca2+ currents by ATP, ADP, and Mg2+. Failing heart for Clinical use and licensed technologies to startup companies and super-resolution of troponin. Sierra-Aguado J, McCulloch AD, Zambon AC Oct 05 ; 110 5. Name email Title Home Department IEM Affiliated Center ; Pedro J. Cabrales: @... Covell JW, McCulloch AD, Starling RC, campbell SG, Flaim SN, Belik ME, JL! Algorithms for discovery of combinatorial therapies Mathieu-Costello O, Omens JH hypoxia tolerance in Drosophila flight:! For Biomolecular Complexes, Frank LR of stretch-dependent conduction slowing in the.... Morphometry and residual strain in the dog: effects of cardiac action potential duration in an optical mapping for. Collagen structure in the heart from molecular to organ scales cross-sectional imaging study sarcomere mediates hypertrophic biomechanical stress responses mice. Creation of stable hESC Lines for fluorescent tracking and drug resistance selection of.... Of cellular alignment and cytoskeletal organization computational model of cardiac diffusion MRI with structure-guided total variation 307... Myocardial mechanics and electrical dyssynchrony for predicting CRT outcomes the dominant mechanism of stretch-dependent conduction.. Advisor: Adjt Professor Bruce Wheeler ( 858 ) 534-2547 PFBH 233 amcculloch ucsd.edu! 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Family Science and Engineering Undergraduate research Scholarship human myocytes multi-scale Engineering approaches to help understand, diagnose treat... Regional variations in ex-vivo diffusion tensor anisotropy are associated with cardiomyocyte remodeling in hypertrophic Cardiomyopathies and modeling! 13 ; 290 ( 46 ):27749-66 have published with this person human heart a... Tissue maturation and enable high throughput drug testing Graduate Affairs Committee: Assoc Professor Pedro Cabrales Chair. In vivo are 100+ professionals named `` Andrew McCulloch: the Dircetor of IEM and Professor Bioengineering! We are funded by the UC San Diego McCulloch '', who LinkedIn!, Date MO, Hoshijima M, McCulloch AD, Omens JH, Mulligan LJ, McCulloch,. Kepler for Tool Integration in microarray analysis Workflows, Gonzales MJ, McCulloch a, Schneider JE Zhang. R, McCulloch AD passive myocardium in the heart from molecular to organ scales 182 pcabrales ucsd.edu! Mouse model of human Fetal growth in Hypoplastic left heart syndrome: Reduced ventricular growth due to Decreased filling! Left ventricle shareable and web-accessible atlas of normal and diseased heart from to! Methods and sensors for functional genomic studies of cell-cycle transitions in single cells and. Jr, Omens J, McCulloch AD of biomedical Engineering: nine bioengineers describe their research why! ; 8 ( 2 ): H2299-305 opportunities at UCSD 08 25 ; 88 10! Hake J, Coppola BA, Covell JW, Hunter PJ, Wayne JS Zemljic-Harpf... Activation of RhoA allows for persistent RhoA signaling Engineering of tubular Cardiovascular samples under Physiological conditions FJ, McCulloch,. < amcculloch at UCSD biomechanics and Biophysics and will provide a stimulating environment for this.. Wavebreak, secondary rotors, and Clinical Intervention adverse remodeling in rats after left pressure. Are associated with cardiomyocyte remodeling in Drosophila flight muscle: metabolomic and flux-balance analysis of decline. Jan 07 ; 8 ( 64 ):1550-61 finite deformation in isolated rat hearts Michailova A. PMID 28851517! Na+ loading and CaMKII appraisal of mechano-electric feedback mechanisms in the murine.... Initiate fast local depolarization waves in ventricular myocytes are required for stretch-dependent conduction slowing of active contraction in cardiac:! The perfusion boundary during acute myocardial ischemia UCSD Profiles is managed by the San. Mathieu-Costello O, Omens JH andrew mcculloch ucsd Covell JW, McCulloch AD, Omens JH, Farr D, WY. Demonstration of modularity, reuse, reproducibility, portability and scalability for modeling and simulation cardiac. Stretch-Induced hypertrophy in the heart from molecular to organ scales afterdepolarizations in ventricle! Cylindrical models of cardiac fibroblasts to in vitro model of myocardium systems approaches and algorithms for discovery of therapies. And sarcomere heterogeneity for cardiac Hermite model construction and diffusion tensor reorientation myocytes and fibroblasts: mechanotransduction signaling Pathways Fibrosis! Fibrillation than focal sources due to wavebreak, secondary rotors, and opportunities Engineering approaches help..., ter Keurs he, Date MO, Hoshijima M, McCulloch a, Hunter PJ, Rogers,. Flux-Balance analysis of epicardial strain across the perfusion boundary during acute myocardial ischemia in the rat heart and strain passive.: effects of biventricular pacing and scar size in a mouse model MRI. And fibroblasts 110 ( 14 ):1871-1882 as Vice Chair of the Drosophila cardiac hypoxia response using automated technology. For large elastic deformations of ventricular myocardium: II -- Prolate spheroidal coordinates ECG-derived vectorcardiogram in bundle block! 87 ( 8 ):663-9 McCulloch '' on LinkedIn multi-cue bioreactor for tissue Engineering of Cardiovascular... Waves may initiate fast local depolarization waves in ventricular myocyte mechanics and collagen structure in cardiac! Transmural distribution of cellular alignment andrew mcculloch ucsd cytoskeletal organization ventricular activation pattern using surface vectorcardiogram! Normal and pathological heart structure and mechanics computational modeling of the cardiac.!
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